In the TechEd “Best Practices for Designing and Building Content Management Server Solutions” session presented by Arpan Shah from Microsoft, he went over six best practices for MCMS installs:

• Limit your top-level channels to 12 or less
• Limit the number of postings to 200-300 per channel
• Limit the number of placeholders in a template to 30 or less
• Use the CMS Health Check tool
• Utilize output caching
• Remove the Resolution HTML packager ISAPI filter to boost performance